Why does pepsin become inactive

They are reversibly inactivated at about pH 5 and irreversibly inactivated at pH 7 to 8. In general, secretion of pepsinogens is coupled to secretion of acid from the parietal cell. In vitro studies have demonstrated that secretion is effectively stimulated by agents that stimulate either of two conditions:.

Receptors for many of the hormones listed above have been demonstrated on chief cells and pepsinogen secretion has been stimulated or blocked by exposure to these agents or their antagonists, respectively. View at: Google Scholar H. Goldberg, W. Dodds, S. Gee, C. Montgomery, and F. View at: Google Scholar J. Harmon, L. Johnson, and C. Schweitzer, J. Harmon, B. Bass, and S. G—G, View at: Google Scholar L.

Johnson and J. View at: Google Scholar D. Gotley, A. Morgan, and M. View at: Google Scholar S. Iffikhar, S. Ledingham, R. Steele et al. View at: Google Scholar F. Johnsson, B. Joelsson, C. Floren, and A. View at: Google Scholar M.

Vaezi and J. Kauer, J. Peters, T. DeMeester et al. Nehra, P. Howell, C. Williams, J. Pye, and J. Zhu, C. Hart, D. Sales, and N. Walker and W. Pearson, R. Ward, and A. Allen, D. Hutton, A. Leonard, J. Pearson, and L. John, Ed. Roberts and W. Etherington and W. Tasker, Otitis media with effusion: key factors , Ph.

Campos and J. Piper and B. Johnston, P. Dettmar, B. Bishwokarma, M. Lively, and J. Ten Kate, H. Tuynman, H. Festen, G. Pals, and S. Babaei, V. Bhargava, S. Aalam, M. Scadeng, and R. Scarpignato and I. Labenz, B. Tillenburg, U. Peitz et al. Tamhankar, J. Peters, G. Portale et al. Johnston, J. Knight, P. Dettmar, M. Johnston, C. Wells, J.

Blumin, R. Toohill, and A. View at: Google Scholar R. Franco Jr. Deschler, and P. Version Wells, T. Samuels, and J. Lively et al. View at: Google Scholar G. Gill, N. Johnston, A. Buda et al. View at: Google Scholar T. Samuels, E.

Handler, M. Syring et al. View at: Google Scholar W. Barlow and R. Tobey, S. Hosseini, C. Argote, A. Dobrucali, M. Awayda, and R. Fornari, K. Blondeau et al. Axford, N. Sharp, P. Dettmar et al. Johnson and T. View at: Google Scholar B. Oelschlager, E. Quiroga, J. Isch, and F. Wiener, R. Tsukashima, C. Kelly et al. Ayazi, J. Lipham, J. Hagen et al. Strugala, P. Dettmar, and A. S, Shay, R. Tutuian, D. Sifrim et al. Xiao, J. Lin, T. Cheung et al. Zentilin, E. Iiritano, P.

The hydrogen on pepsin's carboxylic acid in the enzyme active site is then removed, and the enzyme becomes inactive. The chemical reaction catalyzed by pepsin depends on the presence of a protonated carboxylic acid, so the enzyme's activity is highly dependent on the pH of the solution it's in. Low pH leads to high activity and high pH gives little or no activity.

Updated June 25, Acidity Levels of Functional Groups. The Effect of Hydrogen Ions on Humans. Important Buffers in Living Systems.

Enzyme Activity Plotted Against pH. Bibcode : SciMo.. Kinetic evidence for ordered release of products". The Biochemical Journal. Microbial Biotechnology: Principles And Applications. World Scientific Publishing Company. The Journal of General Physiology. Journal of Immunology. Antibodies: a laboratory manual. Cold Spring Harbor, N. Y: Cold Spring Harbor Laboratory. Physiology of the gastrointestinal system.

Swallowing Vomiting. Saliva Gastric acid. Enterogastrone Cholecystokinin I cells Secretin S cells. Intestinal juice. Segmentation contractions Migrating motor complex Borborygmus Defecation.

Submucous plexus Myenteric plexus. Bile Pancreatic juice. Enterohepatic circulation. Peritoneal fluid. Proteases : aspartate proteases EC 3. Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2. Plasmepsin HIV-1 protease. Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. EC number Enzyme superfamily Enzyme family List of enzymes. Categories : CS1 maint: Unrecognized language Articles containing Ancient Greek-language text Protein pages needing a picture Genes on human chromosome 11 Genes on human chromosome 6 Portal templates with all redlinked portals EC 3.

Cookies help us deliver our services. By using our services, you agree to our use of cookies. Namespaces Home Page Discussion.